For research use only. Not for therapeutic Use.
Iberdomide hydrochloride may be useful in the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production.
| Catalog Number | I029032 |
| CAS Number | 1560678-63-8 |
| Synonyms | CC-220 hydrochloride; CC-220 HCl; Iberdomide hydrochloride; Iberdomide HCl |
| Molecular Formula | C25H28ClN3O5 |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride |
| InChI | InChI=1S/C25H27N3O5.ClH/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27;/h1-7,21H,8-16H2,(H,26,29,30);1H/t21-;/m0./s1 |
| InChIKey | VVHQVXXPZDALDV-BOXHHOBZSA-N |
| SMILES | Cl.O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1 |
| Reference | 1: Skinner C, Gaddie J, Palmer KN. Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59-61. PubMed PMID: 236806; PubMed Central PMCID: PMC1673027. |
