Iberdomide hydrochloride

• CAT Number: I029032
• CAS Number: 1560678-63-8
• Molecular Formula: C25H28ClN3O5
• Molecular Weight: 485.96
• Purity: 98%
• Synonyms: CC-220 hydrochloride; CC-220 HCl; Iberdomide hydrochloride; Iberdomide HCl
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (S)-3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
• InChI: InChI=1S/C25H27N3O5.ClH/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27;/h1-7,21H,8-16H2,(H,26,29,30);1H/t21-;/m0./s1
• InChIKey: VVHQVXXPZDALDV-BOXHHOBZSA-N
• SMILES: Cl.O=C1CC[C@H](N2Cc3c(OCc4ccc(CN5CCOCC5)cc4)cccc3C2=O)C(=O)N1

Iberdomide hydrochloride may be useful in the treatment of systemic lupus erythematosus. Iberdomide significantly reduced Ikaros and Aiolos protein levels in B cells, T cells and monocytes. In SLE PBMC cultures, iberdomide inhibited anti-dsDNA and anti-phospholipid autoantibody production.

Reference

1: Skinner C, Gaddie J, Palmer KN. Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma. Br Med J. 1975 Apr 12;2(5962):59-61. PubMed PMID: 236806; PubMed Central PMCID: PMC1673027.