Iberiotoxin TFA

• CAT Number: I040717
• Molecular Formula: C179H274N50O55S7.xC2HF3O2
• Molecular Weight: 4230.85 (free base)
• Purity: ≥95%

Iberiotoxin (TFA) is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels[1][2][3].

Reference

[1]. Galvez A, et al. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem. 1990;265(19):11083-11090.

[2]. Echeverry S, et al. Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. Front Physiol. 2020;11:210.
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[3]. Wang RJ, et al. Downregulation of large conductance calcium-activated potassium channels in paraventricular nucleus contributes to sympathoexcitation in rats with chronic heart failure. Zhonghua Xin Xue Guan Bing Za Zhi. 2018;46(3):178-186.
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