For research use only. Not for therapeutic Use.
Ibezapolstat（Cat No.:I018655）is an investigational antibiotic with potent activity against Clostridioides difficile (C. difficile), a leading cause of healthcare-associated gastrointestinal infections. It works by inhibiting the bacterial enzyme DNA gyrase, essential for DNA replication. Ibezapolstat offers a promising alternative to traditional treatments, particularly in cases of recurrent or multi-drug resistant infections. Its selective mechanism of action targets only C. difficile, minimizing disruption to the gut microbiota. Currently undergoing clinical trials, Ibezapolstat may provide a valuable tool in the fight against C. difficile infections, offering improved efficacy and safety.
| Catalog Number | I018655 |
| CAS Number | 1275582-97-2 |
| Molecular Formula | C₁₈H₂₀Cl₂N₆O₂ |
| Purity | ≥95% |
| Target | Bacterial; DNA/RNA Synthesis |
| IUPAC Name | 2-[(3,4-dichlorophenyl)methylamino]-7-(2-morpholin-4-ylethyl)-1H-purin-6-one |
| InChI | InChI=1S/C18H20Cl2N6O2/c19-13-2-1-12(9-14(13)20)10-21-18-23-16-15(17(27)24-18)26(11-22-16)4-3-25-5-7-28-8-6-25/h1-2,9,11H,3-8,10H2,(H2,21,23,24,27) |
| InChIKey | DEGSGBKTODESHH-UHFFFAOYSA-N |
| SMILES | C1COCCN1CCN2C=NC3=C2C(=O)NC(=N3)NCC4=CC(=C(C=C4)Cl)Cl |
| Reference | [1]. Beverly Murray, et al. In vitro activity of the novel antibacterial agent ibezapolstat (ACX-362E) against Clostridioides difficile. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155.<br>[2]. Andrea Torti, et al. Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds. Curr Enzym Inhib. 2011 Oct; 7(3): 147-153.<br>[3]. Sofya Dvoskin, et al. A Novel Agent Effective against Clostridium difficile Infection. Antimicrob Agents Chemother. 2012 Mar; 56(3): 1624-1626. |
