IBMX

• CAT Number: I002989
• CAS Number: 28822-58-4
• Molecular Formula: C₁₀H₁₄N₄O₂
• Molecular Weight: 222.24
• Purity: ≥95%
• Synonyms: 3-isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione
• Target: Phosphodiesterase (PDE)
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: -20°C
• IC50: 2-50 uM
• IUPAC Name: 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
• InChI: InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
• InChIKey: APIXJSLKIYYUKG-UHFFFAOYSA-N
• SMILES: CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2

IBMX（Cat No.:I002989）, also known as Isobutylmethylxanthine or 1-Methyl-3-Isobutylxanthine, is a non-specific phosphodiesterase (PDE) inhibitor. It exhibits inhibitory activity against PDE3, PDE4, and PDE5 with IC50 values of 6.5±1.2 μM, 26.3±3.9 μM, and 31.7±5.3 μM, respectively. By inhibiting PDE activity, IBMX enhances intracellular levels of cyclic adenosine monophosphate (cAMP), a critical signaling molecule involved in numerous cellular processes. Additionally, IBMX acts as an antagonist for the adenosine A1 receptor.

Reference

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