For research use only. Not for therapeutic Use.
iBRD4-BD1 diTFA (Cat No.: I040177) is a small molecule inhibitor that selectively targets the bromodomain 1 (BD1) of the BRD4 protein. BRD4 is involved in regulating gene transcription through its interaction with acetylated lysine residues on histones. By inhibiting BRD4-BD1, iBRD4-BD1 diTFA disrupts this interaction, potentially modulating the expression of genes related to cancer, inflammation, and other diseases. This compound is used in research to investigate the role of BRD4 in transcriptional regulation and its therapeutic potential in various diseases.
| Catalog Number | I040177 |
| CAS Number | 2839318-20-4 |
| Synonyms | 2-(2-methyl-5-propan-2-ylphenoxy)-4-[3-piperidin-4-yl-5-[4-(trifluoromethyl)phenyl]imidazol-4-yl]pyrimidine;2,2,2-trifluoroacetic acid |
| Molecular Formula | C33H32F9N5O5 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H30F3N5O.2C2HF3O2/c1-18(2)21-5-4-19(3)25(16-21)38-28-34-15-12-24(36-28)27-26(20-6-8-22(9-7-20)29(30,31)32)35-17-37(27)23-10-13-33-14-11-23;2*3-2(4,5)1(6)7/h4-9,12,15-18,23,33H,10-11,13-14H2,1-3H3;2*(H,6,7) |
| InChIKey | GUUBIJTYNCEMRN-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(C)C)OC2=NC=CC(=N2)C3=C(N=CN3C4CCNCC4)C5=CC=C(C=C5)C(F)(F)F.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O |
| Reference | [1]. Anand Divakaran, et al. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. |
