For research use only. Not for therapeutic Use.
Ibrutinib intermediate N-2 (Cat No.: I014818) is a highly selective and irreversible inhibitor of Bruton’s tyrosine kinase (BTK). Ibrutinib intermediate N-2 is an organic synthesis intermediate and pharmaceutical intermediate, which can be used in the laboratory research and development process and chemical pharmaceutical synthesis process, mainly as the raw material drug ibrutinib intermediate.
| Catalog Number | I014818 |
| CAS Number | 330786-24-8 |
| Molecular Formula | C₁₇H₁₃N₅O |
| Purity | ≥95% |
| Target | Btk |
| Storage | Room temperature |
| IUPAC Name | 3-(4-phenoxyphenyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine |
| InChI | InChI=1S/C17H13N5O/c18-16-14-15(21-22-17(14)20-10-19-16)11-6-8-13(9-7-11)23-12-4-2-1-3-5-12/h1-10H,(H3,18,19,20,21,22) |
| InChIKey | YYVUOZULIDAKRN-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=CC=C(C=C2)C3=C4C(=NC=NC4=NN3)N |
| Reference | [1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.<br>[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. |
