Ibutilide Fumarate

• CAT Number: A001208
• CAS Number: 122647-32-9
• Molecular Formula: C44H76N4O10S2
• Molecular Weight: 885.23
• Purity: ≥95%
• Synonyms: U-70226E
• Target: Potassium Channel
• Solubility: >25.6mg/mL in DMSO
• Storage: store at -20℃
• IUPAC Name: (E)-but-2-enedioic acid;N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
• InChI: InChI=1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
• InChIKey: PCIOHQNIRPWFMV-WXXKFALUSA-N
• SMILES: CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O

Ibutilide Fumarate(CAT: A001208) is a potent antiarrhythmic agent widely used in cardiovascular research. It acts as a Class III antiarrhythmic by promoting delayed repolarization of cardiac action potentials through the activation of slow inward sodium channels and inhibition of the rapid component of the delayed rectifier potassium current (IKr). This dual action prolongs the action potential duration and refractoriness, making Ibutilide Fumarate an effective tool for studying atrial fibrillation and flutter. Its specific mechanism aids in understanding cardiac electrophysiology, arrhythmia mechanisms, and the development of targeted therapies to manage rhythm disorders.