IC2418

• CAT Number: I029054
• CAS Number: 1432641-65-0
• Molecular Formula: C18H24N2O
• Molecular Weight: 284.40
• Purity: 98%
• Synonyms: IC2418; IC 2418; IC-2418
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-cycloheptyl-4,6-dimethyl-1H-indole-2-carboxamide
• InChI: InChI=1S/C18H24N2O/c1-12-9-13(2)15-11-17(20-16(15)10-12)18(21)19-14-7-5-3-4-6-8-14/h9-11,14,20H,3-8H2,1-2H3,(H,19,21)
• InChIKey: ANRDRZQBFPDAJD-UHFFFAOYSA-N
• SMILES: O=C(C(N1)=CC2=C1C=C(C)C=C2C)NC3CCCCCC3

IC2418(CAT: I029054) is a potent inhibitor of MmpL3, an essential transporter involved in the biosynthesis and transport of mycolic acids in Mycobacterium tuberculosis. By targeting MmpL3, IC2418 disrupts the bacterial cell envelope, effectively inhibiting the growth of M. tuberculosis, including drug-resistant strains. Its specificity and efficacy make it a valuable compound in tuberculosis research, particularly in the development of novel therapeutics to combat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. IC2418 serves as a critical tool for studying MmpL3 function and advancing the understanding of mycobacterial cell wall biosynthesis and resistance mechanisms.