ICA 069673

• CAT Number: I010929
• CAS Number: 582323-16-8
• Molecular Formula: C11H6ClF2N3O
• Molecular Weight: 269.63
• Purity: ≥95%
• Synonyms: N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
• Target: Potassium Channel
• Solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
• Storage: Store at RT

ICA 069673 (CAT: I010929) is a selective opener of the KV7.2/KV7.3 (KCNQ2/3) channel. KCNQ2/3 channels are a subtype of voltage-gated potassium channels primarily found in the central nervous system. By selectively opening these channels, ICA 069673 enhances the activity of KCNQ2/3 channels, leading to increased potassium ion conductance and membrane hyperpolarization. This modulation of KCNQ2/3 channels has the potential to regulate neuronal excitability and neurotransmitter release. ICA 069673’s selective action on KV7.2/KV7.3 channels makes it a promising candidate for therapeutic applications in the treatment of neuronal hyperexcitability disorders such as epilepsy and neuropathic pain.