For research use only. Not for therapeutic Use.
ICA-105574 (Cat.No:I007249) is a small molecule activator of hERG that binds to the voltage-gated potassium channel with important cardiovascular function.
| Catalog Number | I007249 |
| CAS Number | 316146-57-3 |
| Synonyms | ICA-105574; ICA 105574; ICA105574.;3-nitro-N-[4-(phenoxy)phenyl]benzamide |
| Molecular Formula | C19H14N2O4 |
| Purity | ≥95% |
| Target | Potassium Channel |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 3-nitro-N-(4-phenoxyphenyl)benzamide |
| InChI | InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22) |
| InChIKey | GDWKBKTVROCPNZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)OC2=CC=C(C=C2)NC(=O)C3=CC(=CC=C3)[N+](=O)[O-] |
| Reference | </br>1:Compound ICA-105574 prevents arrhythmias induced by cardiac delayed repolarization. Meng J, Shi C, Li L, Du Y, Xu Y.Eur J Pharmacol. 2013 Oct 15;718(1-3):87-97. doi: 10.1016/j.ejphar.2013.09.011. Epub 2013 Sep 13. PMID: 24041920 </br>2:ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels. Garg V, Stary-Weinzinger A, Sanguinetti MC.Mol Pharmacol. 2013 Apr;83(4):805-13. doi: 10.1124/mol.112.084384. Epub 2013 Jan 14. PMID: 23319419 Free PMC Article</br>3:Effects of an hERG activator, ICA-105574, on electrophysiological properties of canine hearts. Asayama M, Kurokawa J, Shirakawa K, Okuyama H, Kagawa T, Okada J, Sugiura S, Hisada T, Furukawa T.J Pharmacol Sci. 2013;121(1):1-8. Epub 2012 Dec 14. PMID: 23238536 Free Article</br>4:Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574). Gerlach AC, Stoehr SJ, Castle NA.Mol Pharmacol. 2010 Jan;77(1):58-68. doi: 10.1124/mol.109.059543. Epub 2009 Oct 5. PMID: 19805508 Free Article |
