For research use only. Not for therapeutic Use.
ICA (N-(pyridine-2-yl)-4-(pyridine-2-yl)thiazol-2-amine)（Cat No.:I013044） is a compound that acts as an inhibitor of SK channels. It has been found to possess activity against Leishmania, a parasitic protozoan that causes leishmaniasis. ICA demonstrates an IC50 (half maximal inhibitory concentration) of 2.1 µM against Leishmania, indicating its effectiveness in inhibiting the growth or survival of the parasite.
| Catalog Number | I013044 |
| CAS Number | 3374-88-7 |
| Molecular Formula | C₁₃H₁₀N₄S |
| Purity | ≥95% |
| Target | Parasite |
| Solubility | DMSO |
| Storage | Store at -20°C |
| IUPAC Name | N,4-dipyridin-2-yl-1,3-thiazol-2-amine |
| InChI | InChI=1S/C13H10N4S/c1-3-7-14-10(5-1)11-9-18-13(16-11)17-12-6-2-4-8-15-12/h1-9H,(H,15,16,17) |
| InChIKey | RYCUBTFYRLAMFA-UHFFFAOYSA-N |
| SMILES | C1=CC=NC(=C1)C2=CSC(=N2)NC3=CC=CC=N3 |
| Reference | [1]. Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.<br>[2]. Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76. |
