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489-32-7-Icariin Icariin

Icariin

For research use only. Not for therapeutic Use.

  • CAT Number: I003725
  • CAS Number: 489-32-7
  • Molecular Formula: C33H40O15
  • Molecular Weight: 676.60
  • Purity: ≥95%
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Related Small Molecules: Amine-PEG-CH2COOH (MW 2000)     CVT-313     Sphingosine (d14:1)    

Icariin（Cat No.:I003725）is a flavonoid glycoside derived from Epimedium species, traditionally used in Chinese medicine for its health-promoting properties. It is best known for its potential to improve bone health by stimulating osteoblast activity, making it valuable in osteoporosis research. Icariin also exhibits various pharmacological effects, including anti-inflammatory, antioxidant, and neuroprotective activities. Additionally, it has shown potential in enhancing erectile function by increasing nitric oxide levels and inhibiting PDE5, similar to common erectile dysfunction treatments. Icariin’s wide range of therapeutic benefits makes it a significant compound in medicinal research.


Catalog Number I003725
CAS Number 489-32-7
Synonyms

5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one

Molecular Formula C33H40O15
Purity ≥95%
Target Vitamin D Related/Nuclear Receptor
Solubility DMSO: 50 mg/ml
Storage 3 years -20C powder
IUPAC Name 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
InChI InChI=1S/C33H40O15/c1-13(2)5-10-17-19(45-33-28(42)26(40)23(37)20(12-34)46-33)11-18(35)21-24(38)31(48-32-27(41)25(39)22(36)14(3)44-32)29(47-30(17)21)15-6-8-16(43-4)9-7-15/h5-9,11,14,20,22-23,25-28,32-37,39-42H,10,12H2,1-4H3/t14-,20+,22-,23+,25+,26-,27+,28+,32-,33+/m0/s1
InChIKey TZJALUIVHRYQQB-XLRXWWTNSA-N
SMILES C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC2=C(OC3=C(C2=O)C(=CC(=C3CC=C(C)C)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)O)C5=CC=C(C=C5)OC)O)O)O
Reference

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<br>[1]. Li L, et al. Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-κB and modulation of GR in vivo and in vitro. PLoS One. 2014 Aug 4;9(8):e102345.

<br>[2]. Yang H, et al. Icariin Inhibits Foam Cell Formation By Down-Regulating the Expression of CD36 and Up-Regulating the Expression of SR-BI. J Cell Biochem. 2014 Nov 11.

<br>[3]. Shen R, et al. A natural flavonoid glucoside icariin inhibits Th1 and Th17 cell differentiation and ameliorates experimental autoimmune encephalomyelitis. Int Immunopharmacol. 2014 Dec 17;24(2):224-231.

<br>[4]. Zhang ZY, et al. Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis. PLoS One. 2014 Aug 7;9(8):e104616.

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