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-ICBP112 ICBP112

ICBP112

For research use only. Not for therapeutic Use.

  • CAT Number: I029063
  • Molecular Formula: C27H36N2O5
  • Molecular Weight: 468.594
  • Purity: 98%
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Related Small Molecules: OGT 2115     SSAA09E2     Ibudilast    

ICBP112 is a CBP inhibitor.


Catalog Number I029063
Synonyms

ICBP112; ICBP 112; ICBP-112;

Molecular Formula C27H36N2O5
Purity 98%
Solubility To be determined
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name (S)-1-(7-(3,4-dimethoxyphenyl)-9-((1-methylpiperidin-3-yl)methoxy)-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)propan-1-one
InChI InChI=1S/C27H36N2O5/c1-5-26(30)29-11-12-33-27-22(17-29)13-21(20-8-9-23(31-3)24(14-20)32-4)15-25(27)34-18-19-7-6-10-28(2)16-19/h8-9,13-15,19H,5-7,10-12,16-18H2,1-4H3/t19-/m0/s1
InChIKey YKNAKDFZAWQEEO-IBGZPJMESA-N
SMILES O=C(CC)N1CC2=CC(C3=CC(OC)=C(OC)C=C3)=CC(OC[C@@H]4CN(C)CCC4)=C2OCC1
Reference

1: Yuan YG, Wang JL, Mesalam A, Li L, Choi YJ, Talimur Reza AMM, Zhou D, Chen L, Qian C. Nicotinamide-induced mouse embryo developmental defect rescued by resveratrol and I-CBP112. Mol Reprod Dev. 2020 Sep;87(9):1009-1017. doi: 10.1002/mrd.23405. Epub 2020 Aug 20. PMID: 32818292.
2: Yuan YG, Xu L, Zhang S, Mesalam A, Lee KL, Liu H, Joo MD, Idrees M, Kong IK. Polydatin and I-CBP112 protects early bovine embryo against nicotinamide-induced mitochondrial dysfunction. Theriogenology. 2019 Aug;134:1-10. doi: 10.1016/j.theriogenology.2019.05.007. Epub 2019 May 9. PMID: 31108431.
3: Zucconi BE, Makofske JL, Meyers DJ, Hwang Y, Wu M, Kuroda MI, Cole PA. Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP. Biochemistry. 2019 Apr 23;58(16):2133-2143. doi: 10.1021/acs.biochem.9b00160. Epub 2019 Apr 11. PMID: 30924641; PMCID: PMC6948846.
4: Dhaliwal A, Pelka S, Gray DS, Moghe PV. Engineering Lineage Potency and Plasticity of Stem Cells using Epigenetic Molecules. Sci Rep. 2018 Nov 2;8(1):16289. doi: 10.1038/s41598-018-34511-7. PMID: 30389989; PMCID: PMC6215020.
5: Popp TA, Tallant C, Rogers C, Fedorov O, Brennan PE, Müller S, Knapp S, Bracher F. Development of Selective CBP/P300 Benzoxazepine Bromodomain Inhibitors. J Med Chem. 2016 Oct 13;59(19):8889-8912. doi: 10.1021/acs.jmedchem.6b00774. Epub 2016 Sep 27. PMID: 27673482.
6: Zucconi BE, Luef B, Xu W, Henry RA, Nodelman IM, Bowman GD, Andrews AJ, Cole PA. Modulation of p300/CBP Acetylation of Nucleosomes by Bromodomain Ligand I-CBP112. Biochemistry. 2016 Jul 12;55(27):3727-34. doi: 10.1021/acs.biochem.6b00480. Epub 2016 Jul 1. PMID: 27332697; PMCID: PMC5007619.
7: Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Che KH, Bannister A, Robson S, Kumar U, Parr N, Lee K, Lugo D, Jeffrey P, Taylor S, Vecellio ML, Bountra C, Brennan PE, O’Mahony A, Velichko S, Müller S, Hay D, Daniels DL, Urh M, La Thangue NB, Kouzarides T, Prinjha R, Schwaller J, Knapp S. Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy. Cancer Res. 2015 Dec 1;75(23):5106-5119. doi: 10.1158/0008-5472.CAN-15-0236. Epub 2015 Nov 9. PMID: 26552700; PMCID: PMC4948672.

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