ICI-164384

• CAT Number: I029086
• CAS Number: 98007-99-9
• Molecular Formula: C34H55NO3
• Molecular Weight: 525.82
• Purity: 98%
• Synonyms: ICI 164384; ICI164384; ICI-164384; ICIM164384; ICI-M164384; ICI M164384
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Estra-1,3,5(10)-triene-7-undecanamide, N-butyl-3,17-dihydroxy-N-methyl-, (7alpha,17beta)-
• InChI: InChI=1S/C34H55NO3/c1-4-5-22-35(3)32(38)15-13-11-9-7-6-8-10-12-14-25-23-26-24-27(36)16-17-28(26)29-20-21-34(2)30(33(25)29)18-19-31(34)37/h16-17,24-25,29-31,33,36-37H,4-15,18-23H2,1-3H3/t25-,29-,30+,31+,33-,34+/m1/s1
• InChIKey: BVVFOLSZMQVDKV-KXQIQQEYSA-N
• SMILES: CCCCN(C)C(=O)CCCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@H]3CC[C@]4(C)[C@@H](O)CC[C@H]4[C@H]13

ICI-164384 (Cat No.: I029086) is a nonsteroidal pure antiestrogen that acts as an estrogen receptor (ER) antagonist without partial agonist activity. It was developed for research in breast cancer and endocrine disorders, particularly to investigate mechanisms of estrogen receptor modulation. Unlike selective estrogen receptor modulators (SERMs), ICI-164384 completely inhibits estrogenic activity, making it useful in studies requiring total ER blockade. Though never marketed, it served as a precursor to more advanced antiestrogens like fulvestrant (ICI-182780), and is widely used in preclinical cancer research to study ER signaling.

Reference

1. Nicholson RI, Gee JM, Manning DL, Wakeling AE, Montano MM, Katzenellenbogen BS. Responses to pure antiestrogens (ICI 164384, ICI 182780) in estrogen-sensitive and -resistant experimental and clinical breast cancer. Ann N Y Acad Sci. 1995 Jun 12;761:148-63. doi: 10.1111/j.1749-6632.1995.tb31376.x. PMID: 7625718.
2. Coradini D, Biffi A, Pirronello E, Di Fronzo G. The effect of ICI 164384 and beta-interferon on the growth and steroid receptor profile of breast cancer cell lines. Anticancer Res. 1995 Nov-Dec;15(6B):2557-61. PMID: 8669823.