ICI-204448

• CAT Number: M020233
• CAS Number: 121264-04-8
• Molecular Formula: C23H27Cl3N2O4
• Molecular Weight: 501.83
• Purity: ≥95%
• Synonyms: 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid;hydrochloride
• IUPAC Name: 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid
• InChI: InChI=1S/C23H26Cl2N2O4.ClH/c1-26(22(28)12-16-7-8-19(24)20(25)11-16)21(14-27-9-2-3-10-27)17-5-4-6-18(13-17)31-15-23(29)30;/h4-8,11,13,21H,2-3,9-10,12,14-15H2,1H3,(H,29,30);1H
• InChIKey: FNDGLVOYAQNQPE-UHFFFAOYSA-N
• SMILES: CN(C(CN1CCCC1)C2=CC(=CC=C2)OCC(=O)O)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl

ICI-204448(CAT: M020233) is a selective, peripherally restricted κ-opioid receptor (KOR) agonist used primarily in gastrointestinal and pain research. Unlike central KOR agonists, ICI-204448 does not cross the blood-brain barrier significantly, making it ideal for studying peripheral κ-opioid receptor functions without central nervous system side effects. It has been shown to reduce visceral pain and gastrointestinal motility, making it a valuable pharmacological tool for investigating the role of peripheral opioid pathways in conditions such as irritable bowel syndrome and inflammatory pain.