For research use only. Not for therapeutic Use.
Icilin (Cat No.: I003358) is an agonist specifically targeting the non-selective cation channel TRPM8. It exhibits antiproliferative properties and can activate the current of wild-type TRPM8 channels in a calcium-dependent manner. Notably, Icilin has the ability to induce cell cycle arrest in the G1 phase, making it of particular interest in prostate cancer research. Researchers looking to explore its potential therapeutic applications or seeking more information can reach out to us.
| Catalog Number | I003358 |
| CAS Number | 36945-98-9 |
| Synonyms | 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one |
| Molecular Formula | C16H13N3O4 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO: ≥ 54 mg/mL |
| Storage | Room Temperature |
| IUPAC Name | 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one |
| InChI | InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) |
| InChIKey | RCEFMOGVOYEGJN-UHFFFAOYSA-N |
| SMILES | C1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-] |
