Iclepertin

• CAT Number: I029137
• CAS Number: 1421936-85-7
• Molecular Formula: C20H18F6N2O5S
• Molecular Weight: 512.42
• Purity: 98%
• Synonyms: Iclepertin; Iclépertine; Iclepertina; Iclepertinum
• Target: Neuronal Signaling
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: [5-methylsulfonyl-2-[(2R)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-[(1R,5R)-1-[5-(trifluoromethyl)-1,2-oxazol-3-yl]-3-azabicyclo[3.1.0]hexan-3-yl]methanone
• InChI: InChI=1S/C20H18F6N2O5S/c1-10(19(21,22)23)32-14-4-3-12(34(2,30)31)5-13(14)17(29)28-8-11-7-18(11,9-28)15-6-16(33-27-15)20(24,25)26/h3-6,10-11H,7-9H2,1-2H3/t10-,11+,18+/m1/s1
• InChIKey: MYHDQTVHHMSLEF-DDBGAENHSA-N
• SMILES: C[C@H](C(F)(F)F)OC1=C(C=C(C=C1)S(=O)(=O)C)C(=O)N2C[C@@H]3C[C@@]3(C2)C4=NOC(=C4)C(F)(F)F

Iclepertin (Cat No.:I029137) is a selective inhibitor of the epidermal growth factor receptor (EGFR) and its downstream signaling pathways, particularly focusing on the mutant forms of EGFR, such as EGFRvIII. It is being investigated for its potential in treating various cancers, including glioblastoma and non-small cell lung cancer (NSCLC), where EGFR mutations are commonly implicated in tumor growth and resistance to other therapies. By targeting these mutant forms of EGFR, Iclepertin aims to overcome treatment resistance and improve therapeutic outcomes in EGFR-driven cancers.