For research use only. Not for therapeutic Use.
Icosabutate (Cat.No:I007258), also known as PRB-01022 and PRC-4016, is a PPAR agonist potentially for the treatment of hypertriglyceridemia.
| Catalog Number | I007258 |
| CAS Number | 1253909-57-7 |
| Synonyms | PRB-01022; PRC-4016; PRB01022; PRC4016; PRB 01022; PRC 4016;2-(((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaen-1-yl)oxy)butanoic acid |
| Molecular Formula | C24H38O3 |
| Purity | ≥95% |
| Target | PPAR agonist |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | 2-[(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoxy]butanoic acid |
| InChI | InChI=1S/C24H38O3/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-27-23(4-2)24(25)26/h5-6,8-9,11-12,14-15,17-18,23H,3-4,7,10,13,16,19-22H2,1-2H3,(H,25,26)/b6-5-,9-8-,12-11-,15-14-,18-17- |
| InChIKey | VOGXDRFFBBLZBT-AAQCHOMXSA-N |
| SMILES | CCC=CCC=CCC=CCC=CCC=CCCCCOC(CC)C(=O)O |
| Reference | </br>1:Icosabutate, a More Potent Form of Omega 3 Fatty Acids, Shows Promise in Lowering Triglycerides. Riesen WF.Cardiology. 2016;135(1):1-2. doi: 10.1159/000445286. Epub 2016 May 4. No abstract available. PMID: 27160264 </br>2:Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia. Kastelein JJ, Hallén J, Vige R, Fraser DA, Zhou R, Hustvedt SO, Orloff DG, Bays HE.Cardiology. 2016;135(1):3-12. doi: 10.1159/000445047. Epub 2016 May 4. PMID: 27160246 Free Article</br>3:Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial. Bays HE, Hallén J, Vige R, Fraser D, Zhou R, Hustvedt SO, Orloff DG, Kastelein JJ.J Clin Lipidol. 2016 Jan-Feb;10(1):181-91.e1-2. doi: 10.1016/j.jacl.2015.10.012. Epub 2015 Nov 14. PMID: 26892135 |
