For research use only, not for therapeutic use.
ID-8(Cat No.:I001806)is a small-molecule inhibitor of interleukin-8 (IL-8), a cytokine involved in inflammation, angiogenesis, and tumor progression. By blocking IL-8 signaling, ID-8 reduces pro-inflammatory and pro-angiogenic responses, making it valuable in cancer research and studies related to chronic inflammatory diseases. Its inhibitory effects on IL-8 help prevent the recruitment of neutrophils and the formation of new blood vessels that support tumor growth. ID-8’s ability to modulate immune responses makes it a promising tool for investigating targeted therapies in cancer, inflammation, and immune-mediated disorders.
Catalog Number | I001806 |
CAS Number | 147591-46-6 |
Synonyms | 1-(4-methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol |
Molecular Formula | C16H14N2O4 |
Purity | ≥95% |
Target | DYRK |
Solubility | DMSO: ≥ 47 mg/mL |
Storage | -20°C |
IUPAC Name | 1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol |
InChI | InChI=1S/C16H14N2O4/c1-10-16(18(20)21)14-8-5-12(19)9-15(14)17(10)11-3-6-13(22-2)7-4-11/h3-9,19H,1-2H3 |
InChIKey | VVZNWYXIOADGSW-UHFFFAOYSA-N |
SMILES | CC1=C(C2=C(N1C3=CC=C(C=C3)OC)C=C(C=C2)O)[N+](=O)[O-] |
Reference | 1:Int J Oncol. 2001 Sep;19(3):599-607. Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant.Sylvain V,Lafarge S,Bignon YJ, PMID: 11494042 <br /> |