For research use only. Not for therapeutic Use.
ID09 is a Potent Tubulin Polymerization Inhibitor. ID09 showed excellent aqueous solubility and favorable Log P value and displayed noteworthily low nanomolar potency against a variety of tumor cells, including those taxol-resistant ones. ID09 inhibited tubulin polymerization, disrupted cellular microtubule networks by targeting the colchicine site, and promoted HepG2 cell cycle arrest and cell apoptosis. In the HepG2 xenograft mouse model.
| Catalog Number | I029170 |
| Synonyms | ID09; ID 09; ID-09; |
| Molecular Formula | C24H32Cl2N4O3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 7-(3-aminopropoxy)-6-ethoxy-N-(3-ethoxyphenyl)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-3-amine dihydrochloride |
| InChI | InChI=1S/C24H30N4O3.2ClH/c1-4-29-18-9-6-8-17(14-18)26-24-20-12-16-13-21(30-5-2)22(31-11-7-10-25)15-19(16)23(20)28(3)27-24;;/h6,8-9,13-15H,4-5,7,10-12,25H2,1-3H3,(H,26,27);2*1H |
| InChIKey | WYUKVANVWFLCCH-UHFFFAOYSA-N |
| SMILES | CN1N=C(NC2=CC=CC(OCC)=C2)C3=C1C4=C(C=C(OCC)C(OCCCN)=C4)C3.[H]Cl.[H]Cl |
| Reference | 1: Cui YJ, Liu C, Ma CC, Ji YT, Yao YL, Tang LQ, Zhang CM, Wu JD, Liu ZP. SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors. J Med Chem. 2020 Nov 17. doi: 10.1021/acs.jmedchem.0c01345. Epub ahead of print. PMID: 33201714. |
