For research use only. Not for therapeutic Use.
IDE1（Cat No.:I000584）is a selective inhibitor of the enzyme insulin-degrading enzyme (IDE), which plays a key role in regulating insulin and other peptide hormones by breaking them down. By inhibiting IDE, IDE1 has shown potential in increasing insulin levels, making it a promising candidate for treating insulin resistance and type 2 diabetes. Additionally, IDE1 may have neuroprotective effects, as IDE is involved in the degradation of amyloid-beta, a protein implicated in Alzheimer’s disease. Preclinical studies are ongoing to explore IDE1’s therapeutic potential in both metabolic and neurodegenerative disorders.
| Catalog Number | I000584 |
| CAS Number | 1160927-48-9 |
| Synonyms | 2-((E)-((Z)-(6-carboxy-1-hydroxyhexylidene)hydrazono)methyl)benzoic acid |
| Molecular Formula | C15H18N2O5 |
| Purity | ≥95% |
| Target | Organoid |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | Store at +4C |
| IUPAC Name | 2-[(E)-(6-carboxyhexanoylhydrazinylidene)methyl]benzoic acid |
| InChI | InChI=1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+ |
| InChIKey | ABKJCDILEUEJSH-MHWRWJLKSA-N |
| SMILES | C1=CC=C(C(=C1)/C=N/NC(=O)CCCCCC(=O)O)C(=O)O |
| Reference | </br>1:Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold. Hoveizi E, Nabiuni M, Parivar K, Ai J, Massumi M.J Biomed Mater Res A. 2014 Nov;102(11):4027-36. doi: 10.1002/jbm.a.35039. Epub 2014 Jan 10. PMID: 24277503 </br>2:Identification of novel cis-acting elements, IDE1 and IDE2, of the barley IDS2 gene promoter conferring iron-deficiency-inducible, root-specific expression in heterogeneous tobacco plants. Kobayashi T, Nakayama Y, Itai RN, Nakanishi H, Yoshihara T, Mori S, Nishizawa NK.Plant J. 2003 Dec;36(6):780-93. PMID: 14675444 Free Article |
