For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>IDE1 is an inducer of definitive endoderm 1 (IDE1).<br>Target:<br>InVitro: IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hiPSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, Melton’s team showed that Activin A can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin A treatment. Treatment of hiPSCs with IDE1 (2 mM) also leads to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a[1].</p>
| Catalog Number | I000584 |
| CAS Number | 1160927-48-9 |
| Synonyms | 2-((E)-((Z)-(6-carboxy-1-hydroxyhexylidene)hydrazono)methyl)benzoic acid |
| Molecular Formula | C15H18N2O5 |
| Purity | ≥95% |
| Target | Organoid |
| Solubility | DMSO: ≥ 30 mg/mL |
| Storage | Store at +4C |
| InChI | InChI=1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+ |
| InChIKey | ABKJCDILEUEJSH-MHWRWJLKSA-N |
| SMILES | OC(CCCCCC(N/N=C([H])/C1=C(C(O)=O)C=CC=C1)=O)=O |
| Reference | </br>1:Definitive endoderm differentiation of human-induced pluripotent stem cells using signaling molecules and IDE1 in three-dimensional polymer scaffold. Hoveizi E, Nabiuni M, Parivar K, Ai J, Massumi M.J Biomed Mater Res A. 2014 Nov;102(11):4027-36. doi: 10.1002/jbm.a.35039. Epub 2014 Jan 10. PMID: 24277503 </br>2:Identification of novel cis-acting elements, IDE1 and IDE2, of the barley IDS2 gene promoter conferring iron-deficiency-inducible, root-specific expression in heterogeneous tobacco plants. Kobayashi T, Nakayama Y, Itai RN, Nakanishi H, Yoshihara T, Mori S, Nishizawa NK.Plant J. 2003 Dec;36(6):780-93. PMID: 14675444 Free Article |
