IDF-11774

• CAT Number: I020338
• CAS Number: 1429054-28-3
• Molecular Formula: C₂₃H₃₂N₂O₂
• Molecular Weight: 368.51
• Purity: ≥95%
• Target: HIF/HIF Prolyl-Hydroxylase
• Storage: Store at -20°C
• IUPAC Name: 2-[4-(1-adamantyl)phenoxy]-1-(4-methylpiperazin-1-yl)ethanone
• InChI: InChI=1S/C23H32N2O2/c1-24-6-8-25(9-7-24)22(26)16-27-21-4-2-20(3-5-21)23-13-17-10-18(14-23)12-19(11-17)15-23/h2-5,17-19H,6-16H2,1H3
• InChIKey: QGBBBLPWBSWERZ-UHFFFAOYSA-N
• SMILES: CN1CCN(CC1)C(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4

IDF-11774（Cat No.:I020338） is a HIF-1 inhibitor. It reduces the HRE luciferase activity of HIF-1α (IC50 = 3.65 μM) and prevents the accumulation of HIF-1α under hypoxia in HCT116 colon cancer cell line. IDF-11774 reduces cancer cell growth by modulating glycolytic metabolism and energy production in cancer cells.

Reference

[1]. Ban HS, et al. The novel hypoxia-inducible factor-1α inhibitor IDF-11774 regulates cancer metabolism, thereby suppressing tumor growth. Cell Death Dis. 2017 Jun 1;8(6):e2843.