IDH1 Inhibitor 7

• CAT Number: I041736
• CAS Number: 2135309-56-5
• Molecular Formula: C22H24F3N7O
• Molecular Weight: 459.47
• Purity: ≥95%
• Synonyms: (5S)-5-propan-2-yl-1-[2-[[(1S)-1-[1-[4-(trifluoromethyl)phenyl]imidazol-4-yl]ethyl]amino]pyrimidin-4-yl]imidazolidin-2-one
• InChI: InChI=1S/C22H24F3N7O/c1-13(2)18-10-27-21(33)32(18)19-8-9-26-20(30-19)29-14(3)17-11-31(12-28-17)16-6-4-15(5-7-16)22(23,24)25/h4-9,11-14,18H,10H2,1-3H3,(H,27,33)(H,26,29,30)/t14-,18+/m0/s1
• InChIKey: LVRDYDOHWFEBQG-KBXCAEBGSA-N
• SMILES: CC(C)C1CNC(=O)N1C2=NC(=NC=C2)NC(C)C3=CN(C=N3)C4=CC=C(C=C4)C(F)(F)F

IDH1 Inhibitor 7 (Compound 88) is an IDH1 inhibitor with an IC50 of less than 100 nM[1].

Reference

[1]. Lei Jang, et al. Compound having mutant idh inhibitory activity, preparation method and use thereof. Patent WO2017162133A1.