IDO-IN-18

• CAT Number: I041072
• CAS Number: 314027-92-4
• Molecular Formula: C10H8N2O2S
• Molecular Weight: 220.25
• Purity: ≥95%
• Synonyms: 2-phthalazin-1-ylsulfanylacetic acid
• InChI: InChI=1S/C10H8N2O2S/c13-9(14)6-15-10-8-4-2-1-3-7(8)5-11-12-10/h1-5H,6H2,(H,13,14)
• InChIKey: PALYUVYEAVDKLW-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=NN=C2SCC(=O)O

IDO-IN-18（Cat No.:I041072）is a selective small molecule inhibitor targeting indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme involved in tryptophan metabolism and immune system regulation. By inhibiting IDO1, IDO-IN-18 prevents the degradation of tryptophan, which is often exploited by tumors to suppress immune responses and promote tumor growth. This inhibition can restore immune function, enhance T-cell activity, and improve the efficacy of cancer immunotherapies. IDO-IN-18 shows potential as a therapeutic agent for various cancers, particularly those with immune evasion mechanisms, and could be combined with other treatments for enhanced outcomes.