IDO-IN-3

For research use only. Not for therapeutic Use.

  • CAT Number: I046385
  • CAS Number: 2070018-30-1
  • Molecular Formula: C11H12BrFN6O2
  • Molecular Weight: 359.15
  • Purity: ≥95%
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IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM.
IDO-IN-3 (Compound 4c) is a potent (HeLa IC50=98 nM) inhibitor of IDO[1].


Catalog Number I046385
CAS Number 2070018-30-1
Synonyms

4-(2-aminoethylamino)-N’-(3-bromo-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Molecular Formula C11H12BrFN6O2
Purity ≥95%
InChI InChI=1S/C11H12BrFN6O2/c12-7-5-6(1-2-8(7)13)16-11(17-20)9-10(15-4-3-14)19-21-18-9/h1-2,5,20H,3-4,14H2,(H,15,19)(H,16,17)
InChIKey DAPNMIADTFAXEG-UHFFFAOYSA-N
SMILES C1=CC(=C(C=C1N=C(C2=NON=C2NCCN)NO)Br)F
Reference

[1]. Yue EW, et al. INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett. 2017 Mar 6;8(5):486-491.
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