For research use only. Not for therapeutic Use.
IDRA-21 is a positive AMPA receptor modulator. IDRA-21 inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. IDRA 21 enhances ischemic hippocampal neuron injury.
| Catalog Number | R058833 |
| CAS Number | 22503-72-6 |
| Synonyms | 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide; |
| Molecular Formula | C8H9ClN2O2S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at RT |
| IUPAC Name | 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6} |
| InChI | InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3 |
| InChIKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
| SMILES | CC1NC2=C(C=C(C=C2)Cl)S(=O)(=O)N1 |
| Reference | </br>1:The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. Malkova L, Kozikowski AP, Gale K.Neuropharmacology. 2011 Jun;60(7-8):1262-8. doi: 10.1016/j.neuropharm.2010.12.018. Epub 2010 Dec 23. PMID: 21185313 Free PMC Article</br>2:IDRA-21, a positive AMPA receptor modulator, inhibits synaptic and extrasynaptic NMDA receptor mediated events in cultured cerebellar granule cells. Losi G, Puia G, Braghiroli D, Baraldi M.Neuropharmacology. 2004 Jun;46(8):1105-13. PMID: 15111017 </br>3:The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys. Buccafusco JJ, Weiser T, Winter K, Klinder K, Terry AV.Neuropharmacology. 2004 Jan;46(1):10-22. PMID: 14654093 </br>4:The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury. Yamada KA, Covey DF, Hsu CY, Hu R, Hu Y, He YY.Ann Neurol. 1998 May;43(5):664-9. PMID: 9585363 </br>5:Effect of the AMPA receptor modulator IDRA 21 on LTP in hippocampal slices. Arai A, Guidotti A, Costa E, Lynch G.Neuroreport. 1996 Sep 2;7(13):2211-5. PMID: 8930991 </br>6:7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine S,S-dioxide (IDRA 21), a congener of aniracetam, potently abates pharmacologically induced cognitive impairments in patas monkeys. Thompson DM, Guidotti A, DiBella M, Costa E.Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7667-71. PMID: 7644474 Free PMC Article</br>7:7-Chloro-3-methyl-3-4-dihydro-2H-1,2,4 benzothiadiazine S,S-dioxide (IDRA 21): a benzothiadiazine derivative that enhances cognition by attenuating DL-alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (AMPA) receptor desensitization. Zivkovic I, Thompson DM, Bertolino M, Uzunov D, DiBella M, Costa E, Guidotti A.J Pharmacol Exp Ther. 1995 Jan;272(1):300-9. PMID: 7815345 |
