For research use only. Not for therapeutic Use.
Idronoxil（Cat No.:I007265）, also known as Phenoxodiol, is a synthetic flavonoid compound being investigated for its potential anticancer properties. It works by inhibiting key enzymes involved in cancer cell survival, including protein tyrosine kinases and certain metalloproteinases. Phenoxodiol also sensitizes tumor cells to apoptosis (programmed cell death) by disrupting mitochondrial function and modulating the activity of survival pathways. It has shown promise in preclinical and clinical studies for treating various cancers, including ovarian and prostate cancers. Phenoxodiol is being explored as an alternative or adjunct to traditional chemotherapy treatments due to its potentially lower toxicity.
| Catalog Number | I007265 |
| CAS Number | 81267-65-4 |
| Synonyms | NV-06; NV06; NV 06; Dehydroequol. Idronoxil; Phenoxodiol; Haginin E.;3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol |
| Molecular Formula | C15H12O3 |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | soluble in DMSO, not soluble in water. |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 3-(4-hydroxyphenyl)-2H-chromen-7-ol |
| InChI | InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2 |
| InChIKey | ZZUBHVMHNVYXRR-UHFFFAOYSA-N |
| SMILES | C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O |
| Reference | </br>1: Mahoney S, Arfuso F, Millward M, Dharmarajan A. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110. doi: 10.1186/s12935-014-0110-z. eCollection 2014. PubMed PMID: 25400509; PubMed Central PMCID: PMC4231195. |
