For research use only. Not for therapeutic Use.
IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].
IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine[1].
IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse[1].
| CAS Number | 1141-41-9 |
| Synonyms | N,N-dimethyl-4-(1-methylpyridin-1-ium-4-yl)aniline;iodide |
| Molecular Formula | C14H17IN2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H17N2.HI/c1-15(2)14-6-4-12(5-7-14)13-8-10-16(3)11-9-13;/h4-11H,1-3H3;1H/q+1;/p-1 |
| InChIKey | CAMWVBRDIKKGII-UHFFFAOYSA-M |
| SMILES | C[N+]1=CC=C(C=C1)C2=CC=C(C=C2)N(C)C.[I-] |
| Reference | [1]. Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018. |
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