Ifabotuzumab

• CAT Number: I041840
• CAS Number: 2147698-66-4
• Purity: ≥95%

Ifabotuzumab (KB004) is an IgG1κ antibody targeting EphA3 (KD=610 pM). Ifabotuzumab induces tumor cell apoptosis, activates Antibody-dependent cell mediated cytotoxicity (ADCC), and damages tumor vasculature. Ifabotuzumab reduces human idiopathic pulmonary fibrosis (IPF) CCR10+ cells and improves pulmonary fibrosis[1][2].
Ifabotuzumab (5 mg/kg; i.p.; twice weekly for 5 weeks) improve pulmonary fibrosis in human mouse model[1].

Reference

[1]. Hohmann MS, et al. Antibody-mediated depletion of CCR10+EphA3+ cells ameliorates fibrosis in IPF. JCI Insight. 2021 Jun 8;6(11):e141061.
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[2]. Swords R T,et al. KB004, a novel non-fucosylated humaneered® antibody, targeting EphA3, is active and well tolerated in a phase I/II study of advanced hematologic malignancies[J]. Blood, 2014, 124(21): 3756.