IFN alpha-IFNAR-IN-1 hydrochloride

• CAT Number: I029207
• CAS Number: 2070014-98-9
• Molecular Formula: C18H18ClNS
• Molecular Weight: 315.86
• Purity: ≥95%
• Synonyms: N-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine;hydrochloride
• InChI: InChI=1S/C18H17NS.ClH/c1-19-13-15-8-3-5-11-17(15)20-18-12-6-9-14-7-2-4-10-16(14)18;/h2-12,19H,13H2,1H3;1H
• InChIKey: QTESJCPDPNGOLF-UHFFFAOYSA-N
• SMILES: CNCC1=CC=CC=C1SC2=CC=CC3=CC=CC=C32.Cl

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM)[1].
IFN alpha-IFNAR-IN-1 (compound 1) (18 μM; 24 h) specifically inhibits MVA-induced IFN-a responses by BMpDCs[1].

Reference

[1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.
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