For research use only. Not for therapeutic Use.
iFSP1 (Cat No.:I016161) is a small molecule designed to inhibit the FSP1 (Ferroptosis Suppressor Protein 1) enzyme, which plays a critical role in preventing ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation. FSP1 is involved in the cellular defense against oxidative stress and ferroptosis, making it an important target in diseases like cancer, neurodegeneration, and ischemia. iFSP1 has shown potential in modulating ferroptosis pathways, with ongoing research to explore its therapeutic applications in various diseases.
| Catalog Number | I016161 |
| CAS Number | 150651-39-1 |
| Molecular Formula | C₂₀H₁₃N₅ |
| Purity | ≥95% |
| Target | Ferroptosis |
| Storage | Store at -20°C |
| IUPAC Name | 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile |
| InChI | InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3 |
| InChIKey | FNESYDFRCQEEKA-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N |
| Reference | [1]. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698. |
