For research use only, not for therapeutic use.
iFSP1 (Cat No.:I016161) is a potent, selective, and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1/AIFM2), with an EC50 value of 103nM. iFSP1 can selectively induce ferroptosis in GPX4 knockout Pfa1 cells and HT1080 cells overexpressing FSP1.
| Catalog Number | I016161 |
| CAS Number | 150651-39-1 |
| Molecular Formula | C₂₀H₁₃N₅ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile |
| InChI | InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3 |
| InChIKey | FNESYDFRCQEEKA-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)C2=C(C3=NC4=CC=CC=C4N3C(=C2C#N)N)C#N |
| Reference | [1]. Doll S, et al. FSP1 is a glutathione-independent ferroptosis suppressor.Nature. 2019 Nov;575(7784):693-698. |
