For research use only. Not for therapeutic Use.
IGF-1R inhibitor-2 (example 121) is an insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Downregulation of IGF-1R can reverse the transformed phenotype of tumor cells and potentially render them susceptible to apoptosis[1].
| Catalog Number | I045178 |
| CAS Number | 1116236-15-7 |
| Synonyms | 2-fluoro-6-[[2-[(6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide |
| Molecular Formula | C24H24FN7O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H24FN7O2/c1-32-9-7-13-11-19(34-2)18(10-14(13)12-32)29-24-30-22-15(6-8-27-22)23(31-24)28-17-5-3-4-16(25)20(17)21(26)33/h3-6,8,10-11H,7,9,12H2,1-2H3,(H2,26,33)(H3,27,28,29,30,31) |
| InChIKey | FDCFRUWNFPYFBR-UHFFFAOYSA-N |
| SMILES | CN1CCC2=CC(=C(C=C2C1)NC3=NC4=C(C=CN4)C(=N3)NC5=C(C(=CC=C5)F)C(=O)N)OC |
| Reference | [1]. Stanley Dawes Chamberlain, et al. IR receptor tyrosine kinase and ALK kinase for treating cancer. WO2009020990 A1. |
