For research use only. Not for therapeutic Use.
IGS-1.76 efficiently inhibits the human NCS-1/Ric8a complex. IGS-1.76 shows a significantly increased affinity for hNCS-1 and is able to modulate the hNCS-1/Ric8a interaction efficiently[1].
IGS-1.76 is a Drosophila NCS-1/IGS-1.76 complex inhibitor[1].
| Catalog Number | I045522 |
| CAS Number | 313480-47-6 |
| Synonyms | N-(1,3-benzothiazol-2-yl)-3,3-diphenylpropanamide |
| Molecular Formula | C22H18N2OS |
| Purity | ≥95% |
| InChI | InChI=1S/C22H18N2OS/c25-21(24-22-23-19-13-7-8-14-20(19)26-22)15-18(16-9-3-1-4-10-16)17-11-5-2-6-12-17/h1-14,18H,15H2,(H,23,24,25) |
| InChIKey | GYQWKTIZRYVFEM-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C(CC(=O)NC2=NC3=CC=CC=C3S2)C4=CC=CC=C4 |
| Reference | [1]. Carlos Roca, et al. Deciphering the Inhibition of the Neuronal Calcium Sensor 1 and the Guanine Exchange Factor Ric8a with a Small Phenothiazine Molecule for the Rational Generation of Therapeutic Synapse Function Regulators. J Med Chem. 2018 Jul 26;61(14 |
