IHCH-7079

• CAT Number: I047707
• CAS Number: 2957888-63-8
• Molecular Formula: C23H29N3O
• Molecular Weight: 363.5
• Purity: ≥95%
• IUPAC Name: (10R,15S)-12-[2-(2-methoxyphenyl)ethyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.05,16.010,15]hexadeca-5,7,9(16)-triene
• InChI: InChI=1S/C23H29N3O/c1-24-14-15-26-20-11-13-25(12-10-17-6-3-4-9-22(17)27-2)16-19(20)18-7-5-8-21(24)23(18)26/h3-9,19-20H,10-16H2,1-2H3/t19-,20-/m0/s1
• SMILES: CN1CCN2[C@H]3CCN(C[C@H]3C4=C2C1=CC=C4)CCC5=CC=CC=C5OC

IHCH-7079 is a 5-HT2A receptor arrestin-biased agonist with a Ki value of 16.98 nM. IHCH-7079 displayed antidepressant-like activity in mice but without hallucinogenic effects.
Keywords: IHCH-7079 | Supplier | 5-HT2A agonist | IHCH7079 | IHCH 7079 | CAS [2957888-63-8] | Serotonin | 5-HT2A | Agonist | Receptors | Antidepressant

Reference

D Cao et al. Structure-based discovery of nonhallucinogenic psychedelic analogs. Science. 2022 Jan 28;375(6579):403-411.