For research use only. Not for therapeutic Use.
IHR 1(CAT: I011240) is a potent Smo (Smoothened) antagonist. It has an IC50 value of 7.6 nM, indicating its high potency in inhibiting Smoothened, a key component of the Hedgehog signaling pathway. Importantly, IHR 1 exhibits selectivity for the Hedgehog pathway over other signaling pathways, such as Wnt and Notch. In in vitro studies, IHR 1 has been shown to block the accumulation of Smoothened in the primary cilium, which is an important cellular organelle involved in Hedgehog signaling.
| Catalog Number | I011240 |
| CAS Number | 548779-60-8 |
| Synonyms | N,N/’-1,4-Phenylenebis[2,5-dichlorobenzamide] |
| Molecular Formula | C20H12Cl4N2O2 |
| Purity | ≥95% |
| Target | Smo |
| Solubility | Soluble to 20 mM in DMSO with gentle warming |
| Storage | Store at +4°C |
| IUPAC Name | 2,5-dichloro-N-[4-[(2,5-dichlorobenzoyl)amino]phenyl]benzamide |
| InChI | InChI=1S/C20H12Cl4N2O2/c21-11-1-7-17(23)15(9-11)19(27)25-13-3-5-14(6-4-13)26-20(28)16-10-12(22)2-8-18(16)24/h1-10H,(H,25,27)(H,26,28) |
| InChIKey | VCLHHRGZKNUOAQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1NC(=O)C2=C(C=CC(=C2)Cl)Cl)NC(=O)C3=C(C=CC(=C3)Cl)Cl |
