For research use only. Not for therapeutic Use.
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC50 value of <0.1 µM[1].
IK-930 (compound I-32) (10 mg/kg; p.o.) shows good pharmacokinetic parameters with Cmax of 1088 ng/mL, AUC 0-last of 4581 ng*h/mL in BALB/c mice[1].
| Catalog Number | I040928 |
| CAS Number | 2563892-44-2 |
| Synonyms | N-methyl-3-(1-methylimidazol-4-yl)-4-[[4-(trifluoromethyl)phenyl]methylamino]benzenesulfonamide |
| Molecular Formula | C19H19F3N4O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C19H19F3N4O2S/c1-23-29(27,28)15-7-8-17(16(9-15)18-11-26(2)12-25-18)24-10-13-3-5-14(6-4-13)19(20,21)22/h3-9,11-12,23-24H,10H2,1-2H3 |
| InChIKey | TVBGCXJDLVRDSU-UHFFFAOYSA-N |
| SMILES | CNS(=O)(=O)C1=CC(=C(C=C1)NCC2=CC=C(C=C2)C(F)(F)F)C3=CN(C=N3)C |
| Reference | [1]. Alfredo C. Castro, et al. Tead inhibitors and uses thereof. WO2020243415A2. |
