IKKε-IN-1

• CAT Number: I001127
• CAS Number: 1292310-49-6
• Molecular Formula: C26H27N5O3
• Molecular Weight: 457.52
• Purity: ≥95%
• Synonyms: 5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile
• Target: IκB/IKK
• Solubility: DMSO: ≤ 21.5 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-2-(oxan-4-yloxy)benzonitrile
• InChI: InChI=1S/C26H27N5O3/c27-18-20-17-19(1-6-25(20)34-23-8-13-32-14-9-23)24-7-10-28-26(30-24)29-21-2-4-22(5-3-21)31-11-15-33-16-12-31/h1-7,10,17,23H,8-9,11-16H2,(H,28,29,30)
• InChIKey: BWABTWGSXHTHCG-UHFFFAOYSA-N
• SMILES: C1COCCC1OC2=C(C=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5)C#N

IKKε-IN-1（Cat No.:I001127）is a selective inhibitor of IκB kinase epsilon (IKKε), an enzyme involved in the activation of the NF-κB signaling pathway. NF-κB is crucial in regulating immune responses, inflammation, and cell survival, and its dysregulation is linked to various diseases, including cancer, autoimmune disorders, and chronic inflammation. By inhibiting IKKε, IKKε-IN-1 helps to suppress this pathway, potentially offering therapeutic benefits in treating inflammatory diseases and certain cancers. It is currently under investigation in preclinical and early clinical studies to evaluate its efficacy and safety as a novel therapeutic agent.

Reference

[1]. Preparation of amino-pyrimidine compounds as inhibitors of TBK1 kinase and IKK kinase epsilon. From PCT Int. Appl. (2011), WO 2011046970 A1 20110421.