IL-4-inhibitor-1

• CAT Number: I029223
• CAS Number: 1332184-63-0
• Molecular Formula: C18H12FN3O2
• Molecular Weight: 321.31
• Purity: ≥95%
• Synonyms: 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)pyridine-3-carbonitrile
• InChI: InChI=1S/C18H12FN3O2/c19-12-4-1-10(2-5-12)15-8-13(14(9-20)18(21)22-15)11-3-6-16(23)17(24)7-11/h1-8,23-24H,(H2,21,22)
• InChIKey: DWZPPBGRCDPFSS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1C2=NC(=C(C(=C2)C3=CC(=C(C=C3)O)O)C#N)N)F

IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM[1].
IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1].
IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1].

Reference

[1]. Sean P Quinnell, et al. A Small-Molecule Inhibitor to the Cytokine Interleukin-4. ACS Chem Biol. 2020 Oct 16;15(10):2649-2654.
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