ILK-IN-1

• CAT Number: I001269
• CAS Number: 1333146-24-9
• Molecular Formula: C30H30F3N5O
• Molecular Weight: 533.59
• Purity: ≥95%
• Target: Integrin
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 0.6 μM

ILK-IN-1 is a novel ILK inhibitor with IC50 of 0.6 μM.IC50 value: 0.6 μMTarget: ILKin vitro: ILK-IN-1 exhibits high potency against a panel of prostate and breast cancer cell lines (IC50, 1-2.5 μM). ILK-IN-1 facilitates the dephosphorylation of Akt at Ser-473 and other ILK targets, including glycogen synthase kinase-3β and myosin light chain. ILK-IN-1 suppresses the expression of the transcription/translation factor YB-1 and its targets HER2 and EGFR in PC-3 cells, which could be rescued by the stable expression of constitutively active ILK. ILK-IN-1 induces autophagy and apoptosis, both of which are integral to its antiproliferative activity.in vivo: ILK-IN-1 is a single oral agent in suppressing PC-3 xenograft tumor growth.

Reference

[1]. Lee SL, et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-6374.