illudin S

• CAT Number: M051025
• CAS Number: 1149-99-1
• Molecular Formula: C15H20O4
• Molecular Weight: 264.321
• Purity: ≥95%
• Synonyms: (2’S,3’R,6’R)-2′,3′-dihydro-3′,6′-dihydroxy-2′-(hydroxymethyl)-2′,4′,6′-trimethyl-spiro[cyclopropane-1,5′-[5H]inden]-7′(6’H)-one
• Target: Apoptosis
• Solubility: Soluble in DMSO
• Storage: Store at -20°C
• IUPAC Name: (1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one
• InChI: InChI=1S/C15H20O4/c1-8-10-9(6-13(2,7-16)12(10)18)11(17)14(3,19)15(8)4-5-15/h6,12,16,18-19H,4-5,7H2,1-3H3/t12-,13+,14+/m1/s1
• InChIKey: DDLLIYKVDWPHJI-RDBSUJKOSA-N
• SMILES: CC1=C2[C@H]([C@](C=C2C(=O)[C@](C13CC3)(C)O)(C)CO)O

Illudin S（Cat No.:M051025）is a potent sesquiterpene compound derived from the mushroom Omphalotus illudens, known for its significant anticancer properties. This natural product exhibits cytotoxic effects by disrupting DNA synthesis and function, leading to apoptosis in cancer cells. Illudin S has shown activity against various tumor types in preclinical studies, making it a candidate for further development in cancer therapeutics. However, its potential clinical application is limited by toxicity concerns, prompting ongoing research into safer derivatives and formulations that could harness its therapeutic effects while minimizing adverse side effects.

Reference

The structure of the basidiomycete metabolites, illudin S and illudin M. McMorris T.C. & Anchel M. J. Am. Chem. Soc. 1963, 85, 831.Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells: Unusually high sensitivity of ercc2 and ercc3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agents. Kelner M.J. et al. Biochem. Pharmacol. 1994, 48, 403.