Iloperidone

• CAT Number: A001028
• CAS Number: 133454-47-4
• Molecular Formula: C24H27FN2O4
• Molecular Weight: 426.48
• Purity: ≥95%
• Synonyms: 133454-47-4; Zomaril; Fanapt; Fanapta; HP-873
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO > 10 mM
• Storage: -20°C
• InChI: 1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3
• InChIKey: XMXHEBAFVSFQEX-UHFFFAOYSA-N
• SMILES: CC(=O)C1=CC(=C(C=C1)OCCCN2CCC(CC2)C3=NOC4=C3C=CC(=C4)F)OC

Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms.

Reference

1: Stassinos G, Klein-Schwartz W. Asenapine, iloperidone and lurasidone exposures
in young children reported to U.S. poison centers. Clin Toxicol (Phila). 2017 Oct
10:1-5. doi: 10.1080/15563650.2017.1388385. [Epub ahead of print] PubMed PMID:
28992737.

2: Singh V, Arnold JG, Prihoda TJ, Martinez M, Bowden CL. An Open Trial of
Iloperidone for Mixed Episodes in Bipolar Disorder. J Clin Psychopharmacol. 2017
Oct;37(5):615-619. doi: 10.1097/JCP.0000000000000764. PubMed PMID: 28817490.

3: Pandeti S, Rout TK, Tadigoppula N, Thota JR. Identification of stress
degradation products of iloperidone using liquid chromatography coupled with an
Orbitrap mass spectrometer. Rapid Commun Mass Spectrom. 2017 Aug
30;31(16):1324-1332. doi: 10.1002/rcm.7907. PubMed PMID: 28556266.

4: Mutlu A, Mutlu O, Ulak G, Akar F, Kaya H, Erden F, Tanyeri P. Superior effects
of quetiapine compared with aripiprazole and iloperidone on MK-801-induced
olfactory memory impairment in female mice. Biomed Rep. 2017 May;6(5):567-570.
doi: 10.3892/br.2017.879. Epub 2017 Mar 23. PubMed PMID: 28515915; PubMed Central
PMCID: PMC5431392.

5: Tonin FS, Wiens A, Fernandez-Llimos F, Pontarolo R. Iloperidone in the
treatment of schizophrenia: an evidence-based review of its place in therapy.
Core Evid. 2016 Dec 14;11:49-61. doi: 10.2147/CE.S114094. eCollection 2016.
Review. PubMed PMID: 28008301; PubMed Central PMCID: PMC5167526.

6: Naglich AC, Nelson LA, Hornstra R Jr. Two Cases of Iloperidone-Related Tardive
Dyskinesia. J Clin Psychopharmacol. 2016 Dec;36(6):742-743. PubMed PMID:
27749678.

7: Pei Q, Huang L, Huang J, Gu JK, Kuang Y, Zuo XC, Ding JJ, Tan HY, Guo CX, Liu
SK, Yang GP. Influences of CYP2D6(*)10 polymorphisms on the pharmacokinetics of
iloperidone and its metabolites in Chinese patients with schizophrenia: a
population pharmacokinetic analysis. Acta Pharmacol Sin. 2016
Nov;37(11):1499-1508. doi: 10.1038/aps.2016.96. Epub 2016 Sep 26. PubMed PMID:
27665849; PubMed Central PMCID: PMC5099419.

8: Amon J, Stephen E, El-Mallakh RS. A case of iloperidone overdose in a
27-year-old man with cocaine abuse. SAGE Open Med Case Rep. 2016 Aug
8;4:2050313X16660485. doi: 10.1177/2050313X16660485. eCollection 2016. PubMed
PMID: 27570623; PubMed Central PMCID: PMC4984480.

9: Weiden PJ, Manning R, Wolfgang CD, Ryan JM, Mancione L, Han G, Ahmed S, Mayo
MG. A Randomized Trial of Iloperidone for Prevention of Relapse in Schizophrenia:
The REPRIEVE Study. CNS Drugs. 2016 Aug;30(8):735-47. doi:
10.1007/s40263-016-0345-4. PubMed PMID: 27379654; PubMed Central PMCID:
PMC4982888.

10: Ravani NN, Katke PH. Iloperidone-induced ejaculatory dysfunction: A case
series. Indian J Psychiatry. 2016 Jan-Mar;58(1):87-9. doi:
10.4103/0019-5545.174392. PubMed PMID: 26985111; PubMed Central PMCID:
PMC4776589.