Ilorasertib hydrochloride

• CAT Number: I018278
• CAS Number: 1847485-91-9
• Molecular Formula: C₂₅H₂₂ClFN₆O₂S
• Molecular Weight: 525.00
• Purity: ≥95%
• Target: Epigenetics

Ilorasertib hydrochloride（Cat No.:I018278）is a selective, small-molecule inhibitor targeting aurora kinases and select receptor tyrosine kinases (RTKs), including VEGFR, PDGFR, and FGFR. This compound disrupts key signaling pathways involved in cell division and tumor angiogenesis, making it a promising candidate in cancer research. By inhibiting aurora kinases, Ilorasertib hydrochloride induces mitotic arrest, leading to apoptosis in rapidly proliferating tumor cells. It has demonstrated potential in preclinical models of cancer, especially for targeting solid tumors and hematologic malignancies, making it a valuable tool for oncology research and drug development.

Reference

[1]. Glaser KB, et al. Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.