IM-12

• CAT Number: I000495
• CAS Number: 1129669-05-1
• Molecular Formula: C₂₂H₂₀FN₃O₂
• Molecular Weight: 377.41
• Purity: ≥95%
• Synonyms: GSK3β Inhibitor XIX
• Target: Stem Cell/Wnt
• Solubility: DMSO: ≥ 54.9 mg/mL
• Storage: -20°C
• IC50: 53 nM [1]
• InChI: InChI=1S/C22H20FN3O2/c1-13-18(16-5-3-4-6-17(16)25-13)19-20(22(28)26(2)21(19)27)24-12-11-14-7-9-15(23)10-8-14/h3-10,24-25H,11-12H2,1-2H3
• InChIKey: ZKJAZFUFPPSFCO-UHFFFAOYSA-N
• SMILES: CC1=C(C2=CC=CC=C2N1)C3=C(C(=O)N(C3=O)C)NCCC4=CC=C(C=C4)F

IM-12 (CAT: I000495) is a potent inhibitor of glycogen synthase kinase-3 beta (GSK-3β) with an IC50 of 53 nM. It exhibits significant activity in various biological assays, with comparable or even superior effects compared to the well-known GSK-3β inhibitor SB-216763. The inhibition of GSK-3β by IM-12 suggests its potential role in modulating GSK-3β-mediated signaling pathways, which are involved in various cellular processes such as cell proliferation, differentiation, and apoptosis.

Reference

[1]. Schmole AC, et al. Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem. 2010 Sep 15;18(18):6785-95.