IM-54

• CAT Number: R064419
• CAS Number: 861891-50-1
• Molecular Formula: C19H23N3O2
• Molecular Weight: 325.40
• Purity: ≥95%
• Synonyms: 1-methyl-3-(1-methylindol-3-yl)-4-(pentylamino)pyrrole-2,5-dione
• InChI: InChI=1S/C19H23N3O2/c1-4-5-8-11-20-17-16(18(23)22(3)19(17)24)14-12-21(2)15-10-7-6-9-13(14)15/h6-7,9-10,12,20H,4-5,8,11H2,1-3H3
• InChIKey: SGLOMINNEBLJFF-UHFFFAOYSA-N
• SMILES: CCCCCNC1=C(C(=O)N(C1=O)C)C2=CN(C3=CC=CC=C32)C

IM-54 is a selective inhibitor of oxidative stress-induced necrosis. IM-54 shows potent inhibitory activity against H2O2-induced necrosis. IM-54 acts as a potential cardioprotective agent and biological tool for investigating the molecular mechanisms of cell death[1][2].
IM-54 selectively inhibits oxidative stress-induced necrosis, but it does not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis[1].
IM-54 shows strong inhibition of H2O2-induced necrosis, with an IC50 of 0.25 μM in HL-60 cells[1].

Reference

[1]. Kosuke Dodo, et al. Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury. ACS Med Chem Lett. 2018 Mar 8; 9(3): 182-187.
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[2]. Mikiko Sodeoka, et al. Development of selective inhibitors of necrosis. Chem Rec. 2010 Oct;10(5):308-14.
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