For research use only. Not for therapeutic Use.
IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM[1].
IM176OUT05 (0.1-10 μM; 24 hour) inhibits mitochondrial function and reduces the oxygen consumption rate (OCR) as a surrogate of mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM[1].
IM176OUT05 (10 μM; 6 days) improves the acquisition and maintenance of stem cell pluripotency of mouse and human induced pluripotent stem cells (iPSCs)[1].
IM176OUT05 (10 and 100 nM) facilitates the transition of glycolytic metabolism and induces of the expression of glycolysis-related genes and ETC complex enzymes[1].
IM176OUT05 (200 μL, 1%; apply to the depilated area, once daily) promotes hair regrowth in mice by stimulating the progression of the hair follicle cycle to the anagen phase and increasing the hair follicle number[1].
| Catalog Number | I041815 |
| CAS Number | 1643659-96-4 |
| Synonyms | 1-(diaminomethylidene)-2-[2-(2-methylphenyl)ethyl]guanidine;hydrochloride |
| Molecular Formula | C11H18ClN5 |
| Purity | ≥95% |
| InChI | InChI=1S/C11H17N5.ClH/c1-8-4-2-3-5-9(8)6-7-15-11(14)16-10(12)13;/h2-5H,6-7H2,1H3,(H6,12,13,14,15,16);1H |
| InChIKey | HUMHPPQJBIWIPM-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC=C1CCN=C(N)N=C(N)N.Cl |
| Reference | [1]. Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50(12):1-15. |
