For research use only. Not for therapeutic Use.
IMAB027 (ASP1650) is a specific anti-CLDN6 mAb, while CLDN6 (Claudin 6) is a tight junction membrane protein, aberrantly expressed in various human cancer types, ovarian cancers particularly. IMAB 027 shows anti-tumor activity, and induces apoptosis in CLDN6+ ovarian and testicular cancer cell lines[1].
IMAB027 specifically binds to CLDN6 rather than other closely related family members, such as Claudins 3, 4, and 9[1].
IMAB027 induces target-selective antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) in CLDN6+ ovarian and testicular cancer cell lines[1].
IMAB027 reduces tumor growth and increases overall survival in xenografted mouse tumors with human CLDN6+ cells[1].
| Catalog Number | I042189 |
| CAS Number | 1650599-68-0 |
| Purity | ≥95% |
| Reference | [1]. Türeci Ö, t al. The anti-claudin 6 antibody, IMAB027, induces antibody-dependent cellular and complement-dependent cytotoxicity in claudin 6-expressing cancer cells[J]. Cancer Research, 2018, 78(13_Supplement): 882-882. |
