IMD-0354

• CAT Number: I005720
• CAS Number: 978-62-1
• Molecular Formula: C15H8ClF6NO2
• Molecular Weight: 383.67
• Purity: ≥95%
• Synonyms: IMD0354;IMD 0354
• Target: IKK
• Solubility: 10 mM in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide
• InChI: InChI=1S/C15H8ClF6NO2/c16-9-1-2-12(24)11(6-9)13(25)23-10-4-7(14(17,18)19)3-8(5-10)15(20,21)22/h1-6,24H,(H,23,25)
• InChIKey: CHILCFMQWMQVAL-UHFFFAOYSA-N
• SMILES: O=C(C1=C(O)C=CC(Cl)=C1)NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

IMD-0354(CAT: I005720) is a potent and selective inhibitor of IKKβ (IκB kinase β), a critical regulator of the NF-κB signaling pathway. By inhibiting IKKβ, IMD-0354 blocks the activation of NF-κB, reducing the expression of pro-inflammatory cytokines and mediators. This compound is widely used in research to study inflammation, immune responses, and cancer, as NF-κB plays a pivotal role in these processes. IMD-0354 is a valuable tool for investigating NF-κB-driven pathways and for preclinical studies aimed at developing therapies for inflammatory diseases, autoimmune disorders, and cancer. Its high specificity and efficacy make it a reliable choice for targeted research.