Imidafenacin HCl

• CAT Number: I029259
• CAS Number: 893421-54-0
• Molecular Formula: C20H22ClN3O
• Molecular Weight: 355.86
• Purity: 98%
• Synonyms: Imidafenacin hydrochloride; Imidafenacin HCl; KRP-197 hydrochloride; ONO-8025 hydrochloride
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Methyl-a,a-diphenyl-1H-imidazole-1-butanamide hydrochloride
• InChI: InChI=1S/C20H21N3O.ClH/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18;/h2-11,13,15H,12,14H2,1H3,(H2,21,24);1H
• InChIKey: KOVKCGOEUKOSFQ-UHFFFAOYSA-N
• SMILES: O=C(N)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3C=CN=C3C.[H]Cl

Imidafenacin HCl(CAT: I029259) is a selective muscarinic acetylcholine receptor antagonist, with high affinity for M3 and M1 receptor subtypes. By inhibiting muscarinic receptors, it reduces overactive detrusor muscle activity, making it a pivotal compound in the study of bladder disorders, particularly overactive bladder (OAB) and urinary incontinence. Imidafenacin HCl is also investigated for its potential to minimize side effects such as dry mouth, owing to its receptor selectivity and reduced systemic distribution. Its pharmacological profile supports research into urothelial dysfunction and the development of targeted therapies for genitourinary disorders.