Imidafenacin

• CAT Number: I002223
• CAS Number: 170105-16-5
• Molecular Formula: C20H21N3O
• Molecular Weight: 319.40
• Purity: ≥95%
• Target: Neuronal Signaling
• Solubility: DMSO：≥ 7.8 mg/mL
• Storage: Store at -20°C
• IC50: 0.3 nM(M3) [1]
• IUPAC Name: 4-(2-methylimidazol-1-yl)-2,2-diphenylbutanamide
• InChI: 1S/C20H21N3O/c1-16-22-13-15-23(16)14-12-20(19(21)24,17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,13,15H,12,14H2,1H3,(H2,21,24)
• InChIKey: SQKXYSGRELMAAU-UHFFFAOYSA-N
• SMILES: CC1=NC=CN1CCC(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)N

Imidafenacin (Cat. No: I002223) is a selective muscarinic receptor antagonist primarily used to treat overactive bladder (OAB). It selectively inhibits M3 and M1 muscarinic receptors, reducing involuntary bladder contractions while minimizing side effects on salivation and cognition. Imidafenacin improves urinary urgency, frequency, and incontinence with a favorable safety profile. Its extended half-life allows for effective symptom control with a lower risk of dry mouth and constipation. It is widely used in urology research and clinical practice for managing bladder dysfunction.

Reference

[1]. Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.
[2]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.