For research use only. Not for therapeutic Use.
Imiloxan (Cat No.: I007284) is a selective α2B-adrenergic receptor antagonist used primarily in pharmacological research to study adrenergic signaling and its role in central nervous system and cardiovascular functions. By selectively blocking α2B receptors, imiloxan helps differentiate the physiological roles of α2-adrenergic receptor subtypes, which regulate blood pressure, neurotransmitter release, and vascular tone. It has also been explored for potential effects on mood and cognition. Imiloxan is a valuable tool for dissecting adrenergic pathways and evaluating receptor-specific drug development strategies.
| CAS Number | 81167-16-0 |
| Synonyms | Imiloxan; RS-21361; RS 21361; RS21361.;2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole |
| Molecular Formula | C14H16N2O2 |
| Purity | ≥95% |
| Target | α2 adrenergic receptor antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 2-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-ethylimidazole |
| InChI | 1S/C14H16N2O2/c1-2-16-8-7-15-14(16)9-11-10-17-12-5-3-4-6-13(12)18-11/h3-8,11H,2,9-10H2,1H3 |
| InChIKey | UXABARREKCJULM-UHFFFAOYSA-N |
| SMILES | CCN1C=CN=C1CC2COC3=CC=CC=C3O2 |
| Reference | </br>1:Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Fitch WL, Chen Y, Liu L, Paehler A, Young M.Drug Metab Lett. 2010 Apr;4(2):77-87. PMID: 20446913 </br>2:The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Takano Y, Takano M, Yaksh TL.Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PMID: 1358645 </br>3:The metabolism of imiloxan hydrochloride in healthy male volunteers. Rush WR, Hall DJ, Graham DJ, Selby IA.Xenobiotica. 1992 Feb;22(2):237-46. PMID: 1352928 </br>4:Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Michel AD, Loury DN, Whiting RL.Br J Pharmacol. 1990 Mar;99(3):560-4. PMID: 1970500 Free PMC Article |
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