For research use only. Not for therapeutic Use.
Imiloxan, also known as RS-21361, is an α2 adrenergic receptor antagonist potentially for the treatment of major depressive disorder.
| Catalog Number | I007284 |
| CAS Number | 81167-16-0 |
| Synonyms | Imiloxan; RS-21361; RS 21361; RS21361.;2-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-1-ethyl-1H-imidazole |
| Molecular Formula | C14H16N2O2 |
| Purity | ≥95% |
| Target | α2 adrenergic receptor antagonist |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| Reference | </br>1:Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan. Fitch WL, Chen Y, Liu L, Paehler A, Young M.Drug Metab Lett. 2010 Apr;4(2):77-87. PMID: 20446913 </br>2:The effect of intrathecally administered imiloxan and WB4101: possible role of alpha 2-adrenoceptor subtypes in the spinal cord. Takano Y, Takano M, Yaksh TL.Eur J Pharmacol. 1992 Sep 4;219(3):465-8. PMID: 1358645 </br>3:The metabolism of imiloxan hydrochloride in healthy male volunteers. Rush WR, Hall DJ, Graham DJ, Selby IA.Xenobiotica. 1992 Feb;22(2):237-46. PMID: 1352928 </br>4:Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Michel AD, Loury DN, Whiting RL.Br J Pharmacol. 1990 Mar;99(3):560-4. PMID: 1970500 Free PMC Article |
